Professor Frances Edwards
Australian National University
Max Plank Institute for Biophysical Chemistry
PhD, Neurophysiology | 1990
University of Sydney
MSc, Pharmacology | 1984
University of Sydney
BSc Hons, Pharmacology | 1980
Frances Edwards graduated in Pharmacology at the University of Sydney, Australia and received her PhD whilst working at the Max-Planck Institute in Germany under the Nobel Prize winner, Prof. Bert Sakmann. After staying on as a postdoctoral fellow in Sakmann's lab, in 1990 she joined David Colquhoun’s group in Pharmacology at UCL as a Wellcome European Fellow. After returning to Australia in 1992 Frances held a Queen Elizabeth II Research Fellowship at the University of Sydney from 1993 until 1996. In 1996 she joined the Department of Physiology at UCL. Until 2010 the focus of the Edwards lab was mechanisms of fast synaptic transmission and the role of dendritic spines in plasticity using electrophysiology and confocal imaging. In 2010 the research direction largely shifted to research on Alzheimer's disease, studying several transgenic mouse models of human mutations in the amyloid pathway or microtubule-associated protein tau. Recently improved knock-in models have been developed and these are now the focus of the lab.
In 1997, Frances Edwards and Maria Fitzgerald set up the MSc Neuroscience at UCL which Edwards then ran with a series of other colleagues until 2013. This is a highly academic research-based degree exposing about 40 students per year to the most recent neuroscience research from across the whole of UCL in the form of research seminars, journal clubs and an extensive research project. Now relieved of this major administrative and teaching load, Frances Edwards continues to contribute to the undergraduate, Masters and PhD courses in Neuroscience, particularly concentrating on the the practical lab experience and library research of undergraduate and graduate students.
Interests Beyond UCL:
Frances Edwards has always been actively interested in issues of the natural environment and now works from home much of the time dividing her time between the Essex coast on the River Crouch and the west coast of Ireland where she and her husband grow trees and are proud to be protecting an old forest on their land on the River Roughty in co. Kerry. They also enjoy sailing on the Irish coast. Other interests include making pottery and in recent years wood turning.
Dr. Damian Cummings
I use single cell and field electrophysiology complemented with fluorescent immunohistochemistry, confocal imaging and behavioural approaches to understand the interactions of neurones and microglia to the development of early Alzheimer's disease pathologies. I am also involved with teaching in both the lab and classroom environments.
Dr. Busra Aynekin
I hold a Doctorate in Medical Genetics and Gene Therapy. Subsequently, as a postdoctoral researcher, I dedicated nearly two years of my career to research at the University College London (UCL). During this time, my focus was on non-diagnostic neurological disorders, and I gained valuable expertise in Whole Exome Sequencing (WES) and long-read sequencing techniques. My research extended to encompass mouse studies and functional investigations, which collectively honed my skills and proficiency in a wide range of laboratory techniques. Presently, I am engaged in postdoctoral work on a research project, where I am committed to advancing our understanding of Alzheimer's disease pathologies.
Throughout my masters and research assistant roles at the Edwards Lab, I focused on using techniques of molecular biology to characterise the microglial response to rising amyloid pathology in APP knock-in mice. Now as a 3rd year PhD student, I use techniques of neurochemistry and molecular biology to assess the interaction of microglia and Alzheimer’s risk genes with varying plaque composition and age. I work in collaboration with Dr Jörg Hanrieder's Neurochemistry group at the University of Gothenburg, Sweden.
I’m a 2nd year PhD student with a medical background. My main PhD thesis focuses on studying aged mice and whether the pathology of Alzheimer’s disease that is caused by the NL-F model is increased with the R47H variant of Trem2. During my first year, I studied how Trem2 R47H variant affects basal synaptic transmission on young pre-weaned mice not having any of the familial genes that lead to AD. This was done using the whole-cell patch clamp technique. Currently, I’m studying how the high fat diet, along with the Trem2 R47H and the NL-F genetic mutations affects the pathology of Alzheimer’s disease in aged mice using electrophysiological field recordings of acute hippocampal slices.
I’m a first-year PhD student collaborating with Dr Jörg Hanrieder's lab at the University of Gothenburg, Sweden. I currently use molecular biology, histological and neurochemical techniques to characterise and study the effect of amyloid-beta induced tau aggregation in various mouse models.
I am a 1st year PhD student working in collaboration with Dr Teresa Niccoli's lab at the Institute of Healthy Ageing at UCL. I will use the Drosophila model of Aβ toxicity followed by mouse models to investigate the function and interaction of synaptic genes. I will use a Gene-switch neuronal driver, neurochemical and molecular biology techniques.
I am a recent Neuroscience MSci graduate from Manchester University. I now work at the Edwards lab as a research assistant. My role primarily involves organising the mice used in the research and providing support to current lab members.
I am an MSc Neuroscience student at UCL and I'm undertaking a research project in the lab this year. My project aims to investigate the effects of a high fat diet on disease pathology and the neuroimmune response in mouse models of Alzheimer's disease.
I am a second-year neuroscience MSc student. In the lab I study the effects of Alzheimer's gene variants combined with a high-fat diet on the synaptic function of aged mice, as a model for understanding the human condition. After a career in business, I have returned to science with the aim of contributing to understanding the physiology of learning and memory and how this is modulated by natural aging and neurological disorders. I hold a first degree in electrical engineering from Bristol University (1982), an MBA from City University Business School (1992) and a PGCE from the UCL Institute of Education (2016).
I'm an MSci Neuroscience student at UCL. I am investigating spatial gene expression in microglia in post-mortem human tissue from Alzheimer’s patients using cell-type enriched transcriptomics. For my fourth-year project, I will be exploring the effects of adding genetic and environmental risk factors to mouse models of Alzheimer's disease.
I’m a 3rd year BSc Biomedical Sciences student at UCL currently working at the Edwards Lab. My current project aims to investigate the mouse model for Alzheimer’s tauopathy regarding the phosphorylation state of tau and its correlation with other cell types and organelles. I will continue this research at the Edwards Lab for my final year research project.
Dr. Jörg Hanrieder - Associate Professor in the Dept. Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University
Prof. John Hardy - Chair of the Molecular Biology of Neurological Disease, UCL Queen Square Institute of Neurology, UCL
Dr. John G Hardy - Senior Lecturer in Materials Chemistry, Department of Chemistry & Materials Science Institute, Lancaster University
Prof. Tammaryn Lashley - Professor of Neuroscience, UCL Queen Square Institute of Neurology, UCL
Dr. Dervis Salih - Senior Research Associate, UCL Queen Square Institute of Neurology, UCL
Dr Sevinc Bayram - Bioinformatician, Hitatchi Rail Europe Ltd
Professor Lion Shahab - Institute of Epidemiology and Health, UCL
Dr Takshashila Tripathi
Dr Sevda Boyanova
Dr Dervis Salih
Dr Sue Robertson
Dr Hemai Parthasarathy
Dr Roberta Donato
Dr Anna De Simoni
Dr Dietlind Koch
Dr Marina Yasvoina
Dr Lily Yu
Dr Katie Stringer
Dr Karina Vitanova
Dr Diana Pamela Benitez
Dr Jonathan Brenton
Dr Wenfei Liu
Dr Tiffany Benway
Dr Zelah Joel
Dr Peter Haslehurst
Dr Joshua Paulin
Dr Caroline Mestrallet
Dr Isabel Dean
Dr Stephanie Parsley
Dr Gareth Price
Ms Rivka Steinberg
Dr Angelo Tedoldi
Masters Students - MSc
Pablo Izquierdo Garrudo
Monica Maria Fernandes Freitas
Patricia Pascual Vargas
Evans Ohenhen Asowata
Shabinah Sahar Ali
Masters Students - MPhil
Masters Students - MRes
Integrated Masters Students - Msci