PUBLICATIONS | Edwards Lab

RECENT PUBLICATIONS

2024

Desai, S., Camporesi, E., Brinkmalm, G., Alatza, A., Wood, J.I., Tripathi, T., Bez, S., Stasyuk, N., Hajar, H.B., Saito, T., Saido, T.C., Hardy, J., Cummings, D.M., Hanrieder, J. and Edwards, F.A (2024). Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer’s disease without mutations in MAPT. BioRXiv. https://doi.org/10.1101/2024.11.04.621900.
Wood, J.I., Dulewicz, M., Ge, J., Stringer, K., Szadziewska, A., Desai, S., Koutarapu, S., Hajar, H.B., Blennow, K., Zetterberg, H., Cummings, D.M., Savas, J.N., Edwards, F.A., and Hanrieder, J. (2024). Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity. bioRxiv. 10.1101/2024.10.08.617019.
Hall, C.M., Roberts, M., Desai, R.A., Cummings, D.M., Bilsland, J., Whiting, P., Smith, K., J., and Edwards, F.A. (2024). Sodium channel inhibitors alter the progress of tangle development in a mouse model of dementia. BioRXiv. https://doi.org/10.1101/2024.08.26.609302.

2022

Wood, J. I., E. Wong, R. Joghee, A. Balbaa, K. S. Vitanova, K. M. Stringer, A. Vanshoiack, S. J. Phelan, F. Launchbury, S. Desai, T. Tripathi, J. Hanrieder, D. M. Cummings, J. Hardy and F. A. Edwards (2022). Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology. Cell Rep 41, 111686. doi: 10.1016/j.celrep.2022.111686

2021

Benitez, D. P., S. Jiang, J. Wood, R. Wang, C. M. Hall, C. Peerboom, N. Wong, K. M. Stringer, K. S. Vitanova, V. C. Smith, D. Joshi, T. Saito, T. C. Saido, J. Hardy, J. Hanrieder, B. De Strooper, D. A. Salih, T. Tripathi, F. A. Edwards and D. M. Cummings (2021). Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Mol Neurodegener 16(1): 47. doi: 10.1186/s13024-021-00457-0.
Michno, W., K. M. Stringer, T. Enzlein, M. K. Passarelli, S. Escrig, K. Vitanova, J. Wood, K. Blennow, H. Zetterberg, A. Meibom, C. Hopf, F. A. Edwards and J. Hanrieder (2021). Following spatial A aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics. Sci Adv. doi:10.1126/sciadv.abg4855
Chaney, A. M., F. R. Lopez-Picon, S. Serriere, R. Wang, D. Bochicchio, S. D. Webb, M. Vandesquille, M. K. Harte, C. Georgiadou, C. Lawrence, J. Busson, J. Vercouillie, C. Tauber, F. Buron, S. Routier, T. Reekie, A. Snellman, M. Kassiou, J. Rokka, K. E. Davies, J. O. Rinne, D. A. Salih, F. A. Edwards, L. D. Orton, S. R. Williams, S. Chalon and H. Boutin (2021). Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study. Theranostics. doi: 10.7150/thno.56059

2020

Guarascio, R., D. Salih, M. Yasvoina, F. A. Edwards, M. E. Cheetham and J. van der Spuy (2020). Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment. Hum Mol Genet. doi:10.1093/hmg/ddz255
Liu, W., O. Taso, R. Wang, S. Bayram, A. C. Graham, P. Garcia-Reitboeck, A. Mallach, W. D. Andrews, T. M. Piers, J. A. Botia, J. M. Pocock, D. M. Cummings, J. Hardy, F. A. Edwards and D. A. Salih (2020). Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Hum Mol Genet. doi:10.1093/hmg/ddaa209
Vitanova, K.S., Stringer, K.M., Benitez, D.P., Brenton, J., and Cummings, D.M. (2019). Dementia associated with disorders of the basal ganglia. J Neurosci Res. doi: 10.1002/jnr.24508

2019

Edwards, F. (2019). A unifying hypothesis for Alzheimer’s disease: from plaques to neurodegeneration. Trends in Neurosciences. doi:10.1016/j.tins.2019.03.003
Joel, Z., Izquierdo, P., Salih, D. A., Richardson, J. C., Cummings, D. M., & Edwards, F. A. (2019). Improving Mouse Models for Dementia. Are All the Effects in Tau Mouse Models Due to Overexpression?. Cold Spring Harbor Symposia on Quantitative Biology. doi:10.1101/sqb.2018.83.037531

2018

Joel, Z., Izquierdo, P., Liu, W., Hall, C., Roberts, M., Yap, K., . . . Edwards, F. (2018). A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout life. doi:10.1101/420398
Medawar, E., Benway, T. A., Liu, W., Hanan, T. A., Haslehurst, P., James, O. T., . . . Edwards, F. A. (2018). Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146Vtransgenic mice. EBioMedicine. doi:10.1016/j.ebiom.2018.12.006
Medawar, E., Benway, T., Liu, W., Hanan, T. A., Haslehurst, P., James, O. T., . . . Edwards, F. A. (2018). Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic mice. doi:10.1101/420349
Salih, D., Bayram, S., Guelfi, M. S., Reynolds, R. H., Shoai, M., Ryten, M., . . . Escott-Price, V. (2018). Genetic variability in response to Aβ deposition influences Alzheimer's risk. doi:10.1101/437657
Liu, W., Taso, O., Wang, R., Garcia-Reitboeck, P., Andrews, W. D., Piers, T. M., . . . Salih, D. (2018). Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. bioRxiv. doi:10.1101/449884

2017

Cummings, D. M., Benway, T. A., Ho, H., Tedoldi, A., Fernandes Freitas, M. M., Shahab, L., . . . Edwards, F. A. (2017). Neuronal and Peripheral pentraxins modify glutamate release and may interact in blood-brain barrier failure. Cerebral Cortex. doi:10.1093/cercor/bhx046

2016

Paulin, J. J. W., Haslehurst, P., Fellows, A. D., Liu, W., Jackson, J. D., Joel, Z., . . . Edwards, F. A. (2016). Large and small dendritic spines serve different functions in hippocampal synaptic plasticity. Neural Plasticity, 2016, 6170509. doi:10.1155/2016/6170509

2015

Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., . . . Edwards, F. A. (2015). A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell Rep, 10 (4), 633-644. doi:10.1016/j.celrep.2014.12.041
Cummings, D. M., Liu, W., Portelius, E., Bayram, S., Yasvoina, M., Ho, S. -. H., . . . Edwards, F. A. (2015). First effects of rising amyloid-beta in transgenic mouse brain: synaptic transmission and gene expression. BRAIN, 138, 1992-2004. doi:10.1093/brain/awv127
Witton, J., Padmashri, R., Zinyuk, L. E., Popov, V. I., Kraev, I., Line, S. J., . . . Jones, M. W. (2015). Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. NATURE NEUROSCIENCE, 18 (9), 1291-+. doi:10.1038/nn.4072
Hardy, J. G., Hernandez, D. S., Cummings, D. M., Edwards, F. A., Shear, J. B., & Schmidt, C. E. (2015). Multiphoton microfabrication of conducting polymer-based biomaterials. JOURNAL OF MATERIALS CHEMISTRY B, 3 (25), 5001-5004. doi:10.1039/c5tb00104h

2014

Shahab, L., Plattner, F., Irvine, E. E., Cummings, D. M., & Edwards, F. A. (2014). Dynamic range of GSK3α not GSK3β is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses. Hippocampus, 24 (12), 1413-1416. doi:10.1002/hipo.22362